IMR Press / EJGO / Volume 26 / Issue 6 / PII/2005241

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Relationship between angiogenesis and grade of histologic differentiation in endometrial adenocarcinoma

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1 Department of Gynecology, Universidade Federal de Sao Paulo/Escola Paulista de Medicina, Sao Paulo, SP (Brazil)
2 Department of Pathological Anatomy, Universidade Federal de Sao Paulo/Escola Paulista de Medicina, Sao Paulo, SP (Brazil)
3 Department of Pathological Anatomy, Instituto Brasileiro do Controle do Cancer (Brazilian Institute of Cancer Control), Sao Paulo, SP (Brazil)
Eur. J. Gynaecol. Oncol. 2005, 26(6), 599–601;
Published: 10 December 2005

The objective of the study was to quantify vessels and to relate them to the degree of histologic differentiation in endometrial adenocarcinoma. We studied 35 cases of which ten were G 1, 13 G2 and 12 03 adenocarcinomas. The control group consisted of 11 atrophic and 10 proliferative endometria. From each case two histologic sections were obtained: one for hematoxylin-eosin stain­ing and the other for immunohistochemical study with anti-CD34. Vessel count was performed by morphometric study. Mean vessel count was 15.3 for GI; 19 for G2 and 22.7 for 03 adenocarcinomas; in the control group it was 11.6 for atrophic and 13.2 for proliterative endometria. Slightly differentiated adenocarcinoma presented greater angiogenesis than normal and well-differentiated car­cinoma. In contrast, moderately differentiated carcinoma showed greater angiogenicity as related to normal endometrium, but did not differ from other tumoral endometria.

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