IMR Press / EJGO / Volume 26 / Issue 4 / pii/2005199

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Radiation enhances cisplatin-sensitivity in human cervical squamous cancer cells in vitro

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1 Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama (Japan)
2 Department of Physiology, Wakayama Medical University, Wakayama (Japan)
Eur. J. Gynaecol. Oncol. 2005, 26(4), 431–433;
Published: 10 August 2005

Purpose and methods of investigation: Cisplatin (CDDP) is regularly used in concurrent chemoradiotherapy in patients with advanced cervical cancer although an effective protocol of chemoradiotherapy with CDDP has not yet been established. In search of a better cheinoraiotherapy protocol, we investigated both CDDP effects on radiosensitivity and irradiation effects on CD DP-sensitivity using the radiosensitive human cervical squamous cell carcinoma cell line ME 180. Results: We found that COOP did not affect cellular radiosensitivity, and that irradiation significantly enhanced CDDP-sensitivity. Moreover, all the four post-irradation surviving subclones obtained from repetitively irradated MEISO cells showed significantly higher CODP sensitivities than those of the non-irradiated parent cells. Conclusion: These results suggest that an effective protocol would involve the concurrent administration of CDDP with radio­therapy and further administration following completion of radiotherapy in order to achieve higher CDDP-sensitivities.

Cervical cancer
Squamous cell carcinoma
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