European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Radiation enhances cisplatin-sensitivity in human cervical squamous cancer cells in vitro
Purpose and methods of investigation: Cisplatin (CDDP) is regularly used in concurrent chemoradiotherapy in patients with advanced cervical cancer although an effective protocol of chemoradiotherapy with CDDP has not yet been established. In search of a better cheinoraiotherapy protocol, we investigated both CDDP effects on radiosensitivity and irradiation effects on CD DP-sensitivity using the radiosensitive human cervical squamous cell carcinoma cell line ME 180. Results: We found that COOP did not affect cellular radiosensitivity, and that irradiation significantly enhanced CDDP-sensitivity. Moreover, all the four post-irradation surviving subclones obtained from repetitively irradated MEISO cells showed significantly higher CODP sensitivities than those of the non-irradiated parent cells. Conclusion: These results suggest that an effective protocol would involve the concurrent administration of CDDP with radiotherapy and further administration following completion of radiotherapy in order to achieve higher CDDP-sensitivities.