IMR Press / EJGO / Volume 26 / Issue 2 / pii/2005136

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Lymph node pathway in the spread of endometrial carcinoma

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1 Department of Obstetrics and Gynecology, School of Medicine, Kitasato University, Japan
2 Department of Clinical Cytology, Graduate School of Medical Sciences and Department of Pathology, School of Medicine, Kitasato University, Japan
3 Department of Pathology, School of Medicine, Kitasato University, Japan
Eur. J. Gynaecol. Oncol. 2005, 26(2), 167–169;
Published: 10 April 2005
Abstract

Objective: To elucidate the sentinel nodes of endometrial carcinoma, the spread pathway was clarified. The correlation between lymph node spread and other clinicopathological variables was also analyzed Methods: Dissected lymph node samples in 342 patients who underwent pelvic and selective paraaortic lymphadenectomy were reviewed. Pelvic and paraaortic node (PLN and PAN) status was compared with clinicopathological paran1eters. Results: Lymph node metastasis was demonstrated in 52 patients, including 46 cases with PLN metastasis and six patients with inde­pendent PAN metastasis. The metastatic sites were most frequent in the obturator and internal iliac nodes. Eleven of 49 patients who underwent PAN dissection were positive for metastasis. Sixteen of 23 cases with parametrial metastasis also metastasized in the retroperitoneal lymph node. Conclusion: The lymph node spread pathway in endometrial carcinoma consists of a major route via the obturator node or internal iliac node with or without parametrial involvement, and rarely a direct PAN pathway.

Keywords
Endometrial carcinoma
Lymph node metastasis
Spread pattern
Prognostic factor
Staging laparotomy
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