IMR Press / EJGO / Volume 26 / Issue 1 / pii/2005123

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Coexistence of Brenner tumor and struma ovarii: case report

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1 Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe (Japan)
2 Division of Surgical Pathology, Kobe University Graduate School of Medicine, Kobe (Japan)
3 Division of Molecular Pathology, Kobe University Graduate School of Medicine, Kobe (Japan)
Eur. J. Gynaecol. Oncol. 2005, 26(1), 109–110;
Published: 10 February 2005

Background: There has been controversy regarding the histogenesis of Brenner tumors. It is generally accepted that Brenner tumors are derived directly from ovarian surface epithelium, which undergoes metaplasia to form the typical urothelial-like com­ponents, whereas some investigators assume that Brenner tumors arise from immature germ cells. Case: We describe a well-documented case of the coexistence of struma ovarii regarded as a form of teratoma and Brenner tumor in the same ovary. Immunohistologically, not only columnar cells of thyroid follicles, but also transitional cells of Brenner nests were positive for thyroglobulin. Conclusions: In the present case, Brenner tumors and thyroid elements coexisted and were positive for thyroglobulin. While there is strong evidence that pure Brenner tumors originate mostly from the ovarian surface, at least Brenner tumors associated with ter­atomatous elements may have a germ cell origin.

Brenner tumor
Struma ovarii
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