IMR Press / EJGO / Volume 26 / Issue 1 / pii/2005104

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Intratumoral oxygenation of invasive squamous cell carcimoma of the vulva is not correlated with regional lymph node metastasis

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1 Department of Gynecology, Department of Gynecologic Oncology, University of British Columbia, Vancouver (BC)
2 Department of Pathology,Vancouver Cancer Center; British Columbia Cancer Agency, Vancouver (BC) 21
3 Department of Radiation Oncology, Vancouver Cancer Center; British Columbia Cancer Agency, Vancouver (BC) 21
4 Department of Microbiology and Molecular Genetics, University of California-Irvine, College of Medicine, Irvine, CA (USA)
Eur. J. Gynaecol. Oncol. 2005, 26(1), 31–35;
Published: 10 February 2005
Abstract

Introduction: Tumour hypoxia has been found to be assodated with tumour aggressiveness Our pri1:!1ary aim was to explore the relationship between pretreatment tumour oxygenation in primary vulvar carcinoma and nodal : status. Our secondary objective was to assess if there was a relationship between the clinical and biological variables. Methods: 20 women with ISCC of the vulva were assessed with pretreatment primary tumour oxygenation with an Eppendorf pO2 probe. Patients underwent standard surgical management. Pathological assessment of the primary and nodal tissues was then performed. Primary tumour specimens were also stained for microvessel density and carbonic anhydrase IX. The relationship between smoking, preoperative Hgb, tumour CAIX expression, MVD, and Eppendorf pO2 measurements vs nodal metastasis and between these clinical and biological variables was assessed. Results: Seven patients had positive lymph nodes, 13 had negative nodes. While neither current smoking status, tumour size, tumour oxygen measurements, MVD and CAIX expression correlated with metastatic nodal disease, a low preoperative Hgb cor­related with pathological nodal status (p < 0.027). Conclusions: Although this analysis failed to demonstrate a strong correlation between various measures of tumour oxygenation with nodal metastasis, it may be due to the small number of patients. Only preoperative anaemia is correlated with nodal metasta­sis in early ISCC of the vulva.

Keywords
Vulvar cancer
Tumour hypoxia
Nodal metastasis
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