IMR Press / EJGO / Volume 25 / Issue 6 / pii/2004274

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Changes 1n serum CA-125 levels after laparotomy?

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1 Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya (Turkey)
2 Department of Obstetrics and Gynecology; Faculty of Medicine, Gaziantep University, Gaziantep (Turkey)
3 Department of Biochemistry, Faculty of Medicine, Kocaeli University, Kocaeli (Turkey)
4 Department of Public Health, Faculty of Medicine, Gaziantep University, Gaziantep (Turkey)
Eur. J. Gynaecol. Oncol. 2004, 25(6), 733–734;
Published: 10 December 2004

There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy. Therefore we designed this prospective study to evaluate the effects of laparotomy for hysterectomy on serum CA-125 levels. Ninety-four women (mean age 44.6 ± 6.9 years) were included in the study between January, 2001 and April, 2003. Hysterectomies were performed in patients with chronic pelvic pain, dysfunctional uterine bleeding and myoma uteri. Mean serum CA-125 levels of the patients before and after laparotomy were 16.29 ± 8.11 U/ml and 16.37 ± 8.05 U/ml, respectively. The change in serum CA-125 levels prior to the operation was statisti­cally insignificant when compared with the levels obtained at 24 hours after laparotomy (p > 0.05). We found that laparotomy for hys­terectomy did not change the levels of CA-125 at the 24th hour after the operation, indicating either serum CA-125 levels are not cor­related, at least within 24 hours, with peritoneal irritation or peritoneal irritation was minimal or absent in our operations.

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