IMR Press / EJGO / Volume 25 / Issue 6 / pii/2004268

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Ultrasonographic criteria and tumor marker assay are good procedures for the diagnosis of ovarian neoplasia in preselected outpatients

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1 Discipline of Gynecology and Obstetrics, Faculty of Medicine of Triangulo Mineiro, Uberaba-MG (Brazil)
2 Department of Biological Sciences, Faculty of Medicine of Triangulo Mineiro, Uberaba-MG (Brazil)
3 Discipline of Imaging Science, Faculty of Medicine of Triangulo Mineiro, Uberaba-MG (Brazil)
Eur. J. Gynaecol. Oncol. 2004, 25(6), 707–712;
Published: 10 December 2004
Abstract

Purpose of investigation: To identify parameters for the diagnosis of ovarian neoplasia using ultrasonography (US) and serum tumor marker (TM: CA125, CA19.9, CA15.3, AFP, CEA and estradiol) assay. Methods: Prospective study which included 373 women with increased ovarian volume (>18 cm3 in premenopause and > 8 cm3 in postmenopause). US criteria (≥ l) for surgery were: persistent (> 4 months) or increased cyst, cysts with > l thick septum or ≥ 2 thin septa, cyst diameter ≥ 7 cm, vegetation, calcification or cystic predominance (> 50%), solid tumor (> 50%). Doppler with a resistance index (RI) < 0.4 was considered abnormal. Results: Laparotomy was performed in 164 (44%) patients with 66 (40.2%) benign neoplasias and 19 (11.6%) malignant cases (73.6% at Stage I or II). Two hundred and nine patients were maintained on clinical follow-up. The sensitivity for neoplasia and malignant neoplasia was, respectively, for RI: 17 and 63.6 and RI plus TM: 53.1 and 90.9.

Keywords
Ovarian neoplasia
Ultrasonography
Tumor markers
Doppler
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