IMR Press / EJGO / Volume 25 / Issue 5 / pii/2004245

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

p53, c-erbB-2 expression and steroid hormone receptors in breast carcinoma: correlations with histopathological parameters

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1 Department of Pathology, Medical Faculty, Dicle University, Diyarbakzr (Turkey)
Eur. J. Gynaecol. Oncol. 2004, 25(5), 606–610;
Published: 10 October 2004
Abstract

Objective: The aim of the study was to evaluate the p53 tumor suppressor gene, c-erbB-2 and steroid hormone receptor expres­sion in breast carcinoma by immunohistochemistry and to correlate them with different histopathologic parameters. Materials and Methods: p53, c-erbB-2, steroid hormone receptors and their correlation with age, tumor size, histological grade, axillary lymph-node status, and menopausal status were investigated in 65 breast carcinoma cases. All markers were measured immunohistochemically on paraffin sections. Association between estrogen receptor (ER), progesterone receptor (PgR), p53 and c­erbB-2 expression and clinicopathologic variables were assessed by the chi-square test for qualitative parameters. Results: c-erbB-2 staining was found in 35.3% of breast carcinomas and was associated with ductal subtype and age under 35 (p = 0.022, p = 0.003, respectively); p53 staining was seen in 27.6% of cases and was associated with high histological grade and post­menapausal status (p = 0.038, p = 0.002, respectively). Progesterone receptor expression was associated with positive axillary status (p = 0.003). Conclusion: We concluded that expressions of c-erbB-2, p53, ER, and PgR may be used in the evaluation of breast carcinoma. Therefore the present study suggests that p53 expression is a marker of high histological grade in postrnenopausal status, and that c-erbB-2 expression is associated with histologically ductal subtype.

Keywords
Breast carcinoma
p53
c-erbB-2
Estrogen receptor
Progesterone receptor
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