IMR Press / EJGO / Volume 25 / Issue 3 / pii/2004192

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Solitary spleen metastasis and amyloidosis in a patient with endometrial cancer

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1 1st Department of Medicine. National and Kapodistrian University of Athens, Laikon General Hospital, Athens (Greece)
2 Department of Pathology, Hellenic Air Force and VA General Hospital, Athens (Greece)
Eur. J. Gynaecol. Oncol. 2004, 25(3), 391–393;
Published: 10 June 2004
Abstract

Background: In contrast to autopsy findings, solitary splenic metastases from solid tumors are extremely rare. It may occasion­ally be the first manifestation of recurrent solid cancers, and in particular of gynecologic malignancies. Secondary amyloidosis is also found in malignancy. Case: A 52-year-woman originally diagnosed with a Stage IB, grade 2 endometrial carcinoma presented two and a half years later with a paroxysmal non-productive cough, weakness, loss of appetite and daily afternoon fever. On clinical examination wheezing on forced exhalation and painful splenomegaly was found. After an extensive work-up the patient underwent an explorative laparo­tomy and a splenectomy was performed. Histologic examination showed solitary spleen metastasis with amyloidosis. All symptoms resolved. As the patient had received a full course of postoperative irradiation after a total abdominal hysterectomy, six cycles of combination chemotherapy were administered. The patient remains free of recurrence, 46 months later. Conclusion: A case of solitary spleen metastasis with amyloidosis in a patient with endometrial cancer is presented.

Keywords
Solitary spleen metastasis
Amyloidosis
Endometrium
Cancer
Case report
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