IMR Press / EJGO / Volume 25 / Issue 3 / pii/2004174

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

First-line intraperitoneal cisplatin-paclitaxel and intravenous ifosfamide in Stage Ille ovarian epithelial cancer

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1 Department of Gynecology. CHU Bichat-Claude Bernard, Paris (France)
2 CEA, Neurovirology Department, CRSSA, EPHE, Cedex (France)
Eur. J. Gynaecol. Oncol. 2004, 25(3), 327–332;
Published: 10 June 2004
Abstract

Objectives: To determine the feasibility, toxicity and efficacy of a first-line combination of intraperitoneal (IP) paclitaxel and cis­platin and intravenous (IV) ifosfamide in untreated patients with Stage IIIc ovarian cancer after cytoreduction or biopsies only. Methods: Twenty-six patients entered the trial from 1995 to 1999. Twenty underwent initial cytoreduction which was complete, with residual nodules< 0.5 cm or= 0.5 cm in six, five and nine patients, respectively. Six patients underwent biopsies only at initial surgery. Ten cycles of chemotherapy were planned by both routes. Second-look surgery was planned for all patients. Results: Twenty-one (81%) of the 26 patients were in complete clinical remission (CCR) at the time of second-look surgery. Of the 15 patients who underwent second-look surgery, ten were in CCR including seven in complete remission (CR) confirmed patho­logically. Median overall-survival had not been reached at 53 months (range 16-87), and median disease-free survival was 40 months (range 8-85), for a median follow-up of 53 months (range 16-87). Local toxicity consisted mainly of mild abdominal pain. Systemic toxicity was essentially haematological, with eight (31%) grade 3-4 leukopenia. Conclusion: This study has demonstrated the feasibility, moderate toxicity and efficacy of first-line intraperitoneal paclitaxel-cis­platin chemotherapy.

Keywords
Ovarian cancer
Cisplatin
Paclitaxel
Ifosfamide
Sodium thiosulphate
Intraperitoneal chemotherapy
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