IMR Press / EJGO / Volume 25 / Issue 3 / pii/2004171

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Clinical review of 55 cases of malignant ovarian germ cell tumors

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1 Department of Obstetrics/Gynecology, University of Brescia, Brescia (Italy)
Eur. J. Gynaecol. Oncol. 2004, 25(3), 315–320;
Published: 10 June 2004
Abstract

Purpose of investigation: A retrospective analysis of 55 cases of malignant germ cell tumors in a 20-year period was done to eval­uate the impact of conservative surgery and adjuvant treatment on survival and fertility. Methods: Fifty-five cases of malignant ovarian germ cell tumors (MOGCTs) were studied. Mean age was 22 years. Dysgermi­noma was the most common histotype (45%). Results: Thirty-nine patients (71 %) presented with FIGO surgical Stage I disease. Fertility-sparing surgery was performed in 39 (71 %) women. Postoperative systemic chemotherapy was administered to 40 women (73%), 27 (68%) had received conservative treatment. One woman developed renal failure after the first cycle of chemotherapy and died a few days thereafter and there was one case of bleomycin-induced death due to pulmonary fibrosis. There were eight (14.5%) clinical recurrences. Overall survival rate for relapsing women was 75% (6/8). The recurrence rate for women treated conservatively was 15%, and it was 13% for those treated radically. With a median follow-up of 129 months the overall survival rate for the entire study-population was 90.9%. Eleven pregnancies occurred in 36 women treated with fertility-sparing surgery who were of child-bearing age. Conclusion: The management of MOGCTs with fertility-sparing surgery is a safe, practicable treatment option. The majority of these patients can retain normal ovarian function and reproductive potential after chemotherapy treatment.

Keywords
Malignant germ cell tumors
Dysgerminoma
Surgical treatment
Chemotherapy
Fertility
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