IMR Press / EJGO / Volume 24 / Issue 6 / pii/2003227

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Factors affecting outcome after incomplete excision of cervical intraepithelial neoplasia

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1 Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Joannina University Hospital, Greece
2 1st Department of Obstetrics and Gynecology, University of Athens, Alexandra University Hospital, Athens, Greece
3 Department of Pathology, Ioannina University Hospital, Greece
Eur. J. Gynaecol. Oncol. 2003, 24(6), 541–543;
Published: 10 December 2003

Purpose: Conservative treatment for cervical intraepithelial neoplasia (CIN) by ablative or excisional techniques is widely used. However, women with incomplete excision have a variable risk of CIN recurrence. The aim of this study was to identify possible risk factors for recurrence of CIN after large loop excision of the transformation zone (LLETZ) with involved margins of excision. Methods: All cases of women treated with LLETZ for CIN between 1989-2000, in whom histological evaluation of the excised specimen revealed extension of CIN to the excision margins, were retrospectively studied. A woman was considered to have recurrence when she had histologically confirmed CIN following a second LLETZ or hysterectomy during the follow-up period. The characteristics that were examined as possible risk factors were age, parity, smoking habit, grade of initial lesion and extension to the endo- or ectocervical margin. Results: Treatment failure was diagnosed in 18 out of 65 (27.7%) women with involved margins. The only characteristic that reached statistical significance was age. The mean age of women with recurrence was 35.8 years, whereas the mean age of women without recurrence was 32.8 years (p = 0.044). Also, a trend was evident in women with high-grade initial lesions (CIN II-III) (p = 0.168) and involvement of the endocervical margins (p = 0.149). No differences were observed between the two groups regarding parity and smoking habit. Conclusions: Increased age is a risk factor for recurrence in women with incomplete excision of CIN after LLETZ. Larger studies are required for definite conclusions.

Cervical intraepithelial neoplasia
Large loop excision of the transformation zone
Involved margins
Risk factors
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