IMR Press / EJGO / Volume 24 / Issue 6 / pii/2003215

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Improved early detection of cervical intraepithelial lesions by combination of conventional Pap smear and speculoscopy

B. K-J Yu1,4,5,*B. I-T Kuo3M-S Yen1,3N-F Twu1,3C-R Lai2,3P-J Chen7P-S Chien6K-C Chao1,4,5C-C Yuan1,4,5
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1 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan
2 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan
3 Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan
4 National Yang-Ming University, Taiwan
5 National Defense Medical College, Taiwan
6 Armed Forces Keelung Hospital, Taiwan
7 Armed Forces Keelung Hospital, Taiwan
Eur. J. Gynaecol. Oncol. 2003, 24(6), 495–499;
Published: 10 December 2003

Purpose: To evaluate the efficacy of the addition of speculoscopy to a Pap smear in cervical cancer screening. Methods: All women were screened using the Pap smear plus speculoscopy (PapSure) and colposcopy in the multicenter trial. The final diagnosis of each patient was based on a histological evaluation of the colposcopic target biopsy. Results were analyzed using a proportional compare test, sensitivity, specificity and predictive value with significant value determined at less than 0.05. Results: Of 1,717 eligible cases, 26 cases had LGSIL and 16 cases had HGSIL. Of the Pap smears, five cases had LSIL and 14 cases had HGSIL. Of the combination of the PapSure, 23 cases had LGSIL and 16 cases had HGSIL. The sensitivity of the Pap smear to that of PapSure was calculated at 45.2% and 92.9%, respectively (p < 0.001). The estimated cost to detect a cervical lesion using PapSure is less than that of the Pap smear. Conclusion: The addition of speculoscopy along with a Pap smear screening results in early detection of cervical lesions in comparison to the Pap smear alone. This screening combination is also more cost-effective and requires fewer visits to the clinic in com­parison to a Pap smear screening alone.

Cervical cancer screening
Papanicolaou smear
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