IMR Press / EJGO / Volume 24 / Issue 6 / pii/2003208

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Distinguished Expert Series

BRCA susceptibility genes - A Review of current conservative management of BRCA mutation carriers

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1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel
2 Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Ramal Aviv, Israel
Eur. J. Gynaecol. Oncol. 2003, 24(6), 463–466;
Published: 10 December 2003
Abstract

Three options for the management of a patient carrying a deleterious mutation in the BRCA gene exist: close surveillance, chemoprevention and prophylactic surgical procedures. We aimed at reviewing the current knowledge on the conservative management of patients who are found to be carriers of the BRCA susceptibility genes. Recent literature in the English language was reviewed for publications containing the conservative management of BRCA mutation-carriers. Close surveillance for the breasts includes breast self-examination, clinical examination by a specialist and breast imaging techniques - mammography and magnetic resonance imaging. Ovarian surveillance includes pelvic examination, transvaginal ultrasonography and blood CA-125 measurements. Age at beginning of examinations and their frequency are discussed. Chemoprevention includes tamoxifen and oral contraceptives for breast and ovarian cancer prevention, respectively.

Keywords
BRCA mutation
Breast cancer
Ovarian cancer
Chemoprevention
Mammography
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