IMR Press / EJGO / Volume 24 / Issue 5 / pii/2003202

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report

A case of adenocarcinoma of the endometrial type mixed with a clear cell component that metastasized to the vagina

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1 Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Japan
Eur. J. Gynaecol. Oncol. 2003, 24(5), 435–437;
Published: 10 October 2003
Abstract

We present a patient with adenocarcinoma of the endometrial type mixed with a clear cell component (AMC) that metastasized to the vagina and one of the pelvic lymp nodes. She underwent a radical hysterectomy and pelvic and paraaortic lymphadenectomy, and then received postoperative adjuvant chemotherapy. Histologic features of the endometrial tumor included clear cell adenocar­cinoma with an approximate 10% extent to endometrioid adenocarcinoma. On the other hand, histologic examination on the vaginal tumor predominatly showed clear cell adenocarcinoma and also revealed endometrioid adenocarcinoma to a very small extent, sug­gesting metastasis to the vagina from AMC. On immunohistochemical examination, expression of vascular endothelial growth factor (VEGF)-A, VEGF-C and VEGF-D was apparently stronger in the component of clear cell adenocarcinoma than in that of endometri­oid adenocarcinoma. She has been a disease-free survivor for 26 months. Interestingly, locations of endometrial and vaginal lesions were consistent with the sites of an intrauterine device and ring pessary insertion, respectively.

Keywords
Adenocarcinoma of the endometrial type mixed with a clear cell component
Vaginal metastasis
Intrauterine device
Ring pessary
VEGF
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