IMR Press / EJGO / Volume 24 / Issue 5 / pii/2003199

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Microvessel density as a prognostic factor in preinvasive and invasive cervical lesions

Show Less
1 Department of Obstetrics and Gynecology, Osmangazi University School of Medicine, Eskisehir, Turkey
2 Department of Pathology, Osmangazi University School of Medicine, Eskisehir, Turkey
Eur. J. Gynaecol. Oncol. 2003, 24(5), 425–428;
Published: 10 October 2003

Objective: To assess angiogenesis in preinvasive and invasive cervical lesions and its prognostic value in squamous cell carci­noma (SCC). Methods: Twenty-seven cervical intraepithelial lesions (CIN I, II and III), 27 Stage lb-Ila SCC and 12 normal cervical epithelium were included in the study. Clinico-pathological prognostic factors were re-evaluated from the patients' files and previous tissue sec­tions. Microvessel density (MVD), a marker for angiogenesis, was assessed from new tissue blocks by an immunohistochemical staining method. Statistical tests included Kruskall-Wallis analysis, the Mann-Whitney U-test, Fisher's exact t-test to analyse the categorical data and Cox regression and Kaplan-Meier survival analyses to define the effect of prognosticators on survival. Results: CIN II and III lesions had significantly higher MVD counts than normal epithelium and CIN I lesions, both of which had similar MVD count. Compared to preinvasive lesions invasive SCC had significantly higher MVD counts. Among SCC cases, only pelvic lymph node involvement appeared to be independent risk factor on unvariate analysis. However, MVD, as a cut-off value of 21 determined by ROC analysis, was found to be an independent prognosticator in early stage SCC cases by multivari­ate analysis. Conclusion: Despite the small number of enrolled cases, the results of this study suggest that angiogenesis involved in the devel­opment and progression of cervical neoplasms and MVD might be used as a prognostic factor.

Cervical intraepithelial neoplasia
Cervical cancer
Microvessel density
Back to top