IMR Press / EJGO / Volume 24 / Issue 5 / pii/2003193

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Pelvic inflammatory disease is a risk factor for cervical cancer

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1 Department of Obstetrics and Gynaecology, Gyula Kenezy County Hospital, Debrecen, Hungary
2 Department of Dermatology and Venerology, Semmelweis University, Budapest, Hungary
3 Department of Dermatology and Venerology, Semmelweis University, Budapest, Hungary
4 Department of Dermatology and Venerology, Semmelweis University, Budapest, Hungary
5 Department of Dermatology and Venerology, Semmelweis University, Budapest, Hungary
Eur. J. Gynaecol. Oncol. 2003, 24(5), 401–404;
Published: 10 October 2003
Abstract

The acquisition of human papillomavirus (HPV), the most important etiological agent of cervical cancer, does not cause clinical complaints. Although HPV spreads together with agents causing pelvic inflammatory disease (PID) with complaints forcing the patient to seek medical advice, PIO has not yet been evaluated as a predictor of cervical cancer. The present study aimed to deter­mine the relationship between PIO and HPV in order to evaluate the possible risk factor role of PID for cervical cancer. Two groups of patients were studied: (i) 2,215 women with PID; (ii) 4,217 women participating in a cervical cancer screening programme who were found to have cytological atypia, mucopurulent cervicitis or other colposcopically detected disorders but were free of symp­toms of PID. The presence of HPV and other STD agents in cervical smears was detected with polymerase-chain reaction. HPV prevalence was 33.74% in patients with PID and 26.40% in the group of women without PID (p < 0.001). This suggests that patients suffering from PIO apparently have a higher risk of cervical cancer.

Keywords
Human papillomaviruses
Pelvic inflammatory disease
Cervical cancer
Polymerase chain reaction
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