IMR Press / EJGO / Volume 24 / Issue 2 / pii/2003133

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

ErbB-2/HER-2 protein expression, serum tumour necrosis factor-α (TFM-α) and soluble tumour necrosis factor receptor-2 (TNFR-2) concentrations in human carcinoma of the uterine cervix

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1 2nd Department of Obstetrics and Gynaecology, Faculty of Medicine, Semmelweis University, Germany
2 Department of Gynaecological Oncology, St. Stephen Hospital, Germany
3 Pathology Institute, Furth, Germany
4 1st Department of Internal Medicine of Kádrolyi Hospital, Budapest, Hungary
Eur. J. Gynaecol. Oncol. 2003, 24(2), 138–142;
Published: 10 April 2003
Abstract

The expression of erbB-2 protein (by immunohistochemistry), serum TNF-α, soluble TNF-receptor 2 (sTNFR-2, ELISA) con­centrations and mitogenic (LPS, ConA, PHA) induced TNF-α production of the peripheral blood mononuclear cells (PBMNC) were studied in 91 (UICC Stage 1:39, Stage 2:33, Stage 3:14, Stage 4:5) patients with carcinoma of the uterine cervix. During a follow­up period of seven years 30 patients died (Stage 4:5, Stage 3:12, Stage 2:11, Stage 1:2). ErbB-2 protein expression was significantly more frequent in patients with UICC Stages 3-4 (14/19), and in those with fatal outcomes (14/30, p < 0.0001, chi-square test). Serum TNF-α (2.70 ± 0.69 pg/mL) and sTNFR-2 (3.85 ± 1.05 ng/mL) concentrations were significantly lower in cancer patients (p < 0.0001, Mann-Whitney test) as compared to 64 age-matched control women (TNF-α: 4.32 ±0.36, TNFR-2: 4.85 ± 0.82). The mitogenic induced TNF-α production of PBMNC was also significantly less with all the three mitogens applied (LPS: 35.24 ± 8.84, ConA: 26.28 ± 7.81, PHA: 20.48 ± 7.04 pg/L million of cells/24 hours, p < 0.0001) as compared to the controls (LPS: 65.33 ± 8.82, ConA: 51.00 ± 8.87, PHA: 41.80 ± 9.01). Serum TNF-α, sTNFR-2 concentrations and the mitogenic induced TNF-α production of PBMNC was significantly decreased in patients with erbB-2 positivity as compared to those with negativity. In conclusion the expression of the oncoprotein and the lower levels of the members of the TNF system seem to be poor prognostic parameters in patients with carcinoma of the uterine cervix.

Keywords
TNF-α
TNFR-2
ErbB-2
Cervical cancer
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