IMR Press / EJGO / Volume 24 / Issue 1 / pii/2003112

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

The role of neoadjuvant chemotherapy for squamous cell cervical cancer (Ib - IIIb): a long-term randomized trial

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1 Division of Obstetrics and Gynecology, Sant’ Andrea Hospital, II School of Medicine, Italy
2 Department of Gynecological Sciences, Perinatology and Child Health, I School of Medicine, University of Rome “La Sapienza”, Italy
Eur. J. Gynaecol. Oncol. 2003, 24(1), 51–59;
Published: 10 February 2003

Objective: to verify whether a regimen of preventive chemotherapy in the treatment of cervical carcinoma allows surgical treatment in a larger number of patients and whether cases treated with this combined neoadjuvant polychemotherapy/surgery regimen improves overall and disease-free survival rates. Design: prospective randomized clinical study. Setting: Department of Gynaecology and Obstetrics, University of Rome “La Sapienza”. method: 192 patients suffering from squamous cell carcinoma of the uterine cervix in Stages Ib-IIIb were randomized to one of the following treatments: three courses of neoadjuvant chemotherapy with cisplatin, vincristine, bleomycin (NACT arm; n = l06); conventional surgery or radiotherapy alone (CO arm; n = 86). One hundred and fifty-six patients in Stage Ib-IIb (n = 86, NACT arm and n = 70, CO arm) and 16 patients in Stage III (NACT arm) who proved to be sensitive to the neoadjuvant chemotherapy, underwent radical hysterectomy. Four Stage III patients not sensitive to chemotherapy and 16 patients, Stage III, of the CO arm underwent radiotherapy. Results: the 5-year overall survival rates for the NACT and CO arm, respectively, were 78.6% and 73.2% in Stages Ib-IIa (p = NS), 68.7% and 64.3% in Stage IIb (p = NS). A 5- year disease-free survival rate for the NACT arm and CO arm, respectively, of 77.1 % and 64.3% in Stages Ib-IIa (p <.05), 56.2% and 57.1 % in Stage IIb (p = NS) was found. Conclusions: the responsiveness of cervical cancer to neoadjuvant chemotherapy allows surgical treatment in a larger number of patients and results in longer overall and disease-free survival.

Cervical cancer
Neoadjuvant chemotherapy
Radical hysterectomy
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