IMR Press / EJGO / Volume 23 / Issue 6 / pii/2002214

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Distinguished Expert Series

How to improve cytologic screening for endocervical adenocarcinoma?

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1 Leiden Cytology and Pathology Laboratory, Leiden (The Netherlands)
2 Pathological Laboratory Dordrecht, Dordrecht (The Netherlands)
3 Department of Biomedical Engineering, University of Groningen, Groningen (The Netherlands)
Eur. J. Gynaecol. Oncol. 2002, 23(6), 481–485;
Published: 10 December 2002

Aim: A retrospective study was undertaken to investigate how to improve the diagnosis of endocervical adenocarcinom ɪn screenɪng programs. Material and Methods: The study group consisted of 29 slides of women diagnosed with cancer but who had nega­tive smears. The slides were subdivided in 12 smears taken less than one year before diagnosis by histology and 17 smears taken between one and 10 years prior to diagnosis. A hundred smears of healthy women were used for com­parison. All smears were studied macroscopically after which both groups of smears were scanned by the Neural Network Scanner (NNS). Differences between groups were studied for statistical significance using Pearson’s Chi­squared test. Findings: The macroscopic parameter of these smears found to be present most frequently was a heavy admixture of blood. The presence of blood (lysed or not) in the smears was equally consistently highlighted by the NNS. Stati­stical significance of the association of this parameter, with the presence of cancer, was demonstrated. Conclusion: The awareness of blood as a background feature of adenocarcinoma of the cervix will help to select cases needing special attention. These difficult bloody smears, studied by light microscopy and by NNS images can also be selected for additional MiB-1 staining. With this approach, blood in smears, otherwise frequently leading to a compromise of classification, can become a blessing in disguise. The diagnosis of endocervical adenocarcinoma in screening smears will therefore be improved.

Adenocarcinoma of the endocervix
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