IMR Press / EJGO / Volume 23 / Issue 5 / pii/2002208

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Vaginal intraepithelial neoplasia: report of 102 cases

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1 Department of Gynaecological Oncology, 1st Department of Obstetrics and Gynaecology, Athens University, Colposcopy and Laser Surgery Unit, Alexandra Hospital, Athens (Greece)
Eur. J. Gynaecol. Oncol. 2002, 23(5), 457–459;
Published: 10 October 2002

Background: Vaginal intraepithelian neoplasia (VAIN) is a rare asymptomatic disorder. The aims of the current study were to profile patients with VAIN and to evaluate the response to treatment. Material and Methods: We reviewed the records of 102 patients with VAIN diagnosed from 1990 to 2000. Results: Patients with VAIN, VAIN, and VAIN, had the following mean ages 44.5, 47.8 and 61.8 years, respectively (p < 0.001). All patients with VAIN were found to have abnormal Papanicolaou smears. Localization of the lesions to the upper third of the vagina was observed in 80% of the cases. Recurrences following laser ablation and partial vaginectomy reached 21%. Patients with minimal VAIN lesions from whom punch biopsies were obtained had the lowest recurrence rate. Multifocality significantly affec­ted the risk of recurrence (p = 0.03). Conclusion: VAIN most often involves the upper third of the vagina and is often multifocal. Patient selection and operator skill have a significant influence on the treatment outcome.

Vaginal intraepithelial neoplasia
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