IMR Press / EJGO / Volume 23 / Issue 5 / pii/2002193

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Correlation of three-dimensional tumor volumetry with cervical cancer prognostic parameters

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1 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taiwan
2 Department of Mechanical Engineering, National Central University, Taiwan (R.O.C.)
3 Department of Radiology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taiwan
Eur. J. Gynaecol. Oncol. 2002, 23(5), 401–404;
Published: 10 October 2002

Objective: Estimation of tumor size by a single diameter is used in the current Federal International Gynecology Oncology (FIGO) cervical cancer staging system. However, the role of three-dimensional volumetry is rarely mentioned. In this study, three kinds of tumor volume estimations were performed and the relationship of these volume estimations among associated cervical cancer pro­gnostic parameters were evaluated. Methods: Thirty patients with newly diagnosed cervical cancer at Taipei Veterans General Hospital were enrolled in the study. Final pathology and associated parametric information was obtained by chart review. The original magnetic resonance (MR) image was reappraised by an experienced radiologist and the tumor volume was estimated using either three axial measurements or the longest axial measurement. The corresponding three-dimensional (3-D) volume was calculated by the integration of lesion areas in different images using volumetric software developed by engineers at National Central University, Taiwan. All data were analyzed separately for correlation with clinical staging, histological differentiation, pelvic lymph node metastasis and survival status. Results: A statistically significant difference in tumor volume estimates was found between 3-D-integration and one-dimensional estimates among tumors with lymph nodes metastasis, cell differentiation and parametrial involvement. Conclusion: This study found that the parameters of lymph node metastasis, parametrial involvement and tumor differentiation are volume-dependent. 3D-tumor volumetry showed superior discrimination of these parameters compared to current single dia­meter evaluation suggesting its potential as a rapid method for initial prediction of prognostic factors in cervical cancer.

Tumor volumetry
3-Dimensional volumetry
Stereologic volumetry
Cervical squamous cell carcinoma
Prognostic. factors
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