IMR Press / EJGO / Volume 23 / Issue 5 / pii/2002192

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Risk factors for ovarian cancer and early-onset breast cancer in Mongolia

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1 Department of Obstetrics and Gynecology, McMaster University, Canada
2 Centre for Research in Women’s Health, Toronto (Canada)
3 National Oncology Hospital, Ulaan Baator (Mongolia)
Eur. J. Gynaecol. Oncol. 2002, 23(5), 397–400;
Published: 10 October 2002
Abstract

Objective: To determine if there are founder BRCA 1 mutations in the Mongolian population. Methods: Seventeen women with ovarian cancer, 14 women with premenopausal breast cancer and one woman with both cancer types were interviewed to obtain family history, and hormonal, reproductive and environment risk factor information. Blood was collected for DNA analysis from these women to determine the frequency of BRCA 1 and BRCA2 mutations in Mongolia. Results: Two patients had two first-degree relatives with cancer and nine women had one first degree relative with cancer. Two women had the unique BRCA 1 mutation previously described. These two women were not related but their parents were from the same tribe and they lived in the same imak (province). Only one other patient was of this tribal background and from the same region; however, she did not have the BRCA l mutation. Conclusion: A substantial proportion of Mongolian woman with ovarian cancer or early-onset breast cancer may be due to a founder BRCA I mutation 3452delA.

Keywords
Ovarian cancer
Breast cancer
Risk factors
Mongolia
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