IMR Press / EJGO / Volume 23 / Issue 3 / pii/2002152

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Extramedullary hematopoiesis in the uterine isthmus: A case report and review of the literature

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1 Consultant in Obstetrics and Gynaecology, Department of Obstetrics and Gynecology, and Department of Pathology, “G. Chatzikosrta” District General State Hospital of oannina, Ioannina (Greece)
2 Consultant in Pathology, Department of Obstetrics and Gynecology, and Department of Pathology, “G. Chatzikosrta” District General State Hospital of oannina, Ioannina (Greece)
3 Registrar in Obstetrics and Gynaecology, Department of Obstetrics and Gynecology, and Department of Pathology, “G. Chatzikosrta” District General State Hospital of oannina, Ioannina (Greece)
4 Director of Pathology, Department of Obstetrics and Gynecology, and Department of Pathology, “G. Chatzikosrta” District General State Hospital of oannina, Ioannina (Greece)
5 Director of Obstetrics and Gynaecology, Department of Obstetrics and Gynecology, and Department of Pathology, “G. Chatzikosrta” District General State Hospital of oannina, Ioannina (Greece)
Eur. J. Gynaecol. Oncol. 2002, 23(3), 227–230;
Published: 10 June 2002
Abstract

Extramedullary hematopoiesis (EH) is the ectopic production of myeloid, erythroid and megakaryocytic elements. In postfetal life it usually occurs in conditions with hyperactive, depleted or infiltrated marrow; it is extremely rare in the genital tract. We report a case of EH in the uterine isthmus (UI) which was found incidentally in a 40-year-old patient who presented with a right ovarian cyst and a history of a right modified radical mastectomy for infiltrating invasive lobular carcinoma one year earlier. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Microscopic examination of UI revealed foci of hematopoiesis, consisting of white blood cell precursors confirmed by positive chloroacetate-esterase staining. Bone marrow biospy showed diffuse infiltration secondary to breast cancer. Further work-up, including a bone scan, showed multiple metastases sugge­sting that the high degree of bone marrow infiltration by neoplasmatic cells had stimulated the EH. In conclusion, the unusual finding of EH in UI heralded widespread infiltration of bone marrow.

Keywords
Hematopoiesis
Extramedullary
Uterus
Bone marrow biopsy
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