IMR Press / EJGO / Volume 23 / Issue 3 / pii/2002142

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Renin-producing serous cystoadenocarcinoma of the ovary: a case report

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1 Department of Obstetrics and Gynecology, Yamanashi Medical University, Yamanashi (Japan)
2 Department of Pathology and Laboratory Medicine, Tohoku Rosai Hospital, Miyagi (Japan)
Eur. J. Gynaecol. Oncol. 2002, 23(3), 183–186;
Published: 10 June 2002

Background: Only a few renin-producing ovarian tumors have been reported, and most such ovarian tumors have been sex cord/stromal tumors. Renin-producing ovarian epithelial tumors are quite rare. Case: A 46-year-old woman presented with hypertension and hypokalemia. Examinations of the patient revealed elevated plasma renin activity, hyperaldosteronism and a pelvic mass. Subsequently, a right ovarian tumor mass was resected. Microscopic obser­vation of the tumor revealed a well-differentiated serous cystadenocarcinoma. Immediately after surgery, blood pressure, serum potassium, plasma renin activity and plasma aldosterone levels returned to normal ranges. RT-PCR analysis and immunohistoche­mical staining of this tumor indicated that it was producing renin. Conclusion: This is the first report of a renin-producing ovarian serous cystadenocarcinoma.

Renin-producing ovarian tumor
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