IMR Press / EJGO / Volume 23 / Issue 2 / pii/2002123

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Is there a link between vulval cancer and blood group?

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1 University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London (UK)
Eur. J. Gynaecol. Oncol. 2002, 23(2), 111–112;
Published: 10 April 2002

Risk factors for squamous cell vulval cancer (SCC) remain unclear though there have been associations with lichen sclerosis, smoking, and vulval intraepithelial neoplasia (VIN). We studied 191 patients who had been referred to the vulva! clinic at the Royal Free Hospital and who had both blood group and histopathology results available. Seventy-two percent of patients with SCC and non-neoplastic epithelial disorders of the vulva (NNEDV) were found to be in blood group A with only 17% in blood group O. Those with SCC associated with VIN had only 30% in blood group A with 50% in blood group O. The control population showed that 38% of the population were in blood group A and 43% were in blood group O. Our results suggest that blood group A is pre­valent in patients with SCC associated with NNEDV but not in those women with squamous vulva! cancer and associated VIN.

Lichen sclerosus
Vulva! cancer
Blood groups
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