IMR Press / EJGO / Volume 23 / Issue 1 / pii/2002110

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Abnormal “low grade” transformation zone: current diagnostic gold standard

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1 Institute of Gynecology and Obstetrics, University of Rome “La Sapienza”, Rome (Italy)
2 Department of Experimental Medicine and Pathology, Section of Virology, University of Rome “La Sapienza”, Rome (Italy)
3 Department of Experimental Medicine and Pathology, University of Rome “La Sapienza”, Rome (Italy)
4 Department of Sciences and Public Health, University of Rome “La Sapienza”, Rome (Italy)
Eur. J. Gynaecol. Oncol. 2002, 23(1), 45–49;
Published: 10 February 2002
Abstract

The aim of this work was to examine different methods of investigation in the diagnosis of the abnormal "low grade" transfor­mation zone of the portio, Over a period of one year 41 patients subjected to colposcopic examination underwent exo-endocervical sampling for oncologic evaluation and for detection of viral and bacterial infections (HPY, HSY, adenovirus, mycoplasmas and chlamydia trachomatis), as well as portio biopsy. A 65.8% correlation was found between cytology and the HPY-DNA test results, while histology and the presence of the HPY virus agreed in 51.4% of cases. In those cases in which minimal histological alterations were found (koilocytosis) a high percen­tage of HPV negativity was found. In discordant negative cytologic tests that were however positive for HPY by PCR, the genoty­pes identified were always 6 and 11.

Keywords
Cervix
Colposcopy
Cytology
Histology
Genital infections
Mycoplasma
HPY
HSY
Adenovirus
Chlamydia trachomatis
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