IMR Press / EJGO / Volume 22 / Issue 6 / pii/2001212

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Reproductive tract pathology in asymptomatic women treated with tamoxifen

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1 Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey
2 Department of Medical Oncology, Hacettepe University School of Medicine, Ankara, Turkey
Eur. J. Gynaecol. Oncol. 2001, 22(6), 466–468;
Published: 10 December 2001
Abstract

Purpose: To determine the long-term effects of tamoxifen on the female reproductive tract in patients with breast cancer. Methods: Forty-nine patients with breast cancer receiving tamoxifen longer than two years were analyzed. All the patients underwent pelvic examination, pap smear, transvaginal ultrasonography, serum CA 125 and dilatation and curettage. Results: There were 16 patients with genital system pathology. Three of them had atypical Pap smears, one with cervical carci­noma and the other two with chronic cervicitis. Two significant ovarian pathologies were found. These were ovarian fibroma, and unilateral derrnoid cyst. There were three patients with endometrial hyperplasia without atypia. Uterine myoma was encountered in seven of the cases. Only one patient had elevated CA I 25 levels despite normal genital examination findings. Conclusion: Since no significant genital pathology attributable to tamoxifen therapy could be detected, the follow-up for gynecologic pathologies in breast cancer patients receiving tamoxifen therapy may be individualized.

Keywords
Tamoxifen
Breast cancer
Endometrial hyperplasia
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