IMR Press / EJGO / Volume 22 / Issue 6 / pii/2001198

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Estrogen receptor expression in an endometrial stromal sarcoma after tamoxif en therapy

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1 Department of Obstetrics and Gynecology, The George Washington University Medical Center, Washington, DC, USA
Eur. J. Gynaecol. Oncol. 2001, 22(6), 417–419;
Published: 10 December 2001

Introduction: Several cases of low-grade endometrial stromal sarcomas in women with breast cancer have been reported to be associated with tamoxifen therapy. Estrogen receptor expression has been used to characterize the partial estrogenic action of tamoxifen on the endometrium and has been found in tamoxifen-associated endometrial pathologies. Case: A low-grade endometrial stromal sarcoma in a woman with a history of breast cancer treated with adjuvant tamoxifen is presented. Steroid receptor studies performed on the tumor were negative for estrogen and positive for progesterone. Conclusion: The absence of estrogen receptor expression suggests that endometrial stromal sarcomas are not necessarily caused by the estrogenic properties of tamoxifen.

Endometrial stromal sarcoma
Estrogen receptor
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