IMR Press / EJGO / Volume 22 / Issue 5 / pii/2001186

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Marginal-zone B-cell lymphoma, extranodal-malt-type: Report of three cases

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1 Department of Histology-Embryology, Democritus University of Thrace, Greece
2 Department of Pathology, Democritus University of Thrace, Greece
3 Department of Radiology, Democritus University of Thrace, Greece
4 Department of Ear, Nose, and Throat Surgery, Regional Hospital of Alexandroupolis, Greece
5 Department of Ophthalmology, Democritus University of Thrace, Greece
6 Department of Cytology, Regional Hospital of Alexandroupolis, Greece
Eur. J. Gynaecol. Oncol. 2001, 22(5), 361–364;
Published: 10 October 2001

A high proportion of extranodal lymphoid infiltrates are diffuse small lymphocytic proliferations and therefore pose a par­ticularly challenging diagnostic problem. Their benign or malignant nature cannot be determined using clinical and radiologic criteria. The application of traditional morphologic criteria (i.e., cytologic maturity and polymorphism favor benignancy, while cytologic atypia and monomorphism favor malignancy), has probably improved diagnostic accuracy. However, these criteria generally have not been helpful in evaluating the large number of lymphoid infiltrates composed of monomorphic collections of small cytologically-mature appearing lymphoid cells and, therefore, have not always accurately predicted clinical behavior. Extranodal lymphoid proliferations are also of considerable biologic interest since their pathogenesis and natural history have not been fully elucidated. Localized non-Hodgkin' s lymphoma, extranodal-MALT-type, was diagnosed in our Department in three cases: Two arose in the orbit and the third one in the tonsil. The tumors had a typical histologic appearance. The microscopical features and immunohisto­chemical profile are discussed.

N H Lymphomas
Orbital lymphoid lesions
Waldeyer' s ring lymphoid lesions
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