IMR Press / EJGO / Volume 22 / Issue 5 / pii/2001180

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Is there a real risk in patients with endometrial carcinoma undergoing diagnostic hysteroscopy (HSC)?

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1 Department of Obtestrics and Gynecology, Palacky University Medical School, Olomouc, The Czech Republic
Eur. J. Gynaecol. Oncol. 2001, 22(5), 342–344;
Published: 10 October 2001

Objetive: The penetration of distention medium into the peritoneal cavity as well as directly into the bloodstream via injured endometrial vessels occurs in a great proportion of patients at hysteroscopy (HSC). This may cause potential risk of dissemination of the malignant cells of endometrial cancer patients. To evaluate the real risk of a poorer prognosis of these patients a prospective multicentric study was started in 1998. Material and Methods: Two groups of patients with endometrial carcinoma have been compared. The diagnosis was made in the study group by HSC and targeted biopsy, while in the control group by classical D&C. At the end of the HSC procedure puncture of the cul de sac was performed and the fluid obtained was cytologically examined. In both groups peritoneal lavage was perfor­med at the beginning of the subsequent operation and the collected fluid was again cytologically examined. In the first phase of the study the cytology findings in both groups were compared. In the second phase which is planned for the next five years, the results of follow-up of both groups of patients will be evaluated. Results: The results were evaluated in 134 patients with HSC and in 61 patients with D&C. In the study group a positive finding of malignant cells from the cul de sac was found in four patients (5.3%), a suspect finding in eight patients (10.7%), and a negative finding in 63 patients (84%). In the remaining 59 patients with HSC no peritoneal fluid was obtained. In the fluid from lavage at the beginning of the operation in the same group of HSC patients, a positive finding of malignant cells was found in 12.1 %, a suspect finding in 18.2%, and a negative finding in 69.7%. In the control group (after D&C) the fluid from lavage contained mali­gnant cells in eight patients (13.6%), suspect cells in 12 patients (20.3%), and no malignant cells in 39 patients (66.1 %). Both groups were comparable for clinical stages of disease. Conclusions: Our results suggest that HSC does not increase the risk of penetration of tumour cells into the peritoneal cavity more than estimates in D&C.

Endometrial cancer
Malignant cell seeding
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