IMR Press / EJGO / Volume 22 / Issue 3 / pii/2001148

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Adenoid cystic carcinoma of Bartholin's gland: A case report

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1 Department of Pathology, University of Rijeka, Rijeka, Croatia
2 Department of Obstetrics and Gynecology, University of Rijeka, Rijeka, Croatia
Eur. J. Gynaecol. Oncol. 2001, 22(3), 213–214;
Published: 10 June 2001

Objective: A case of adenoid cystic carcinoma (ACC) of the Bartholin' s gland in a 34-year-old woman with unusual presentation and early recurrence is reported. Methods: Clinical and histologie features were recorded. Immunohistochemical stains and cell-cycle analysis by flow cytometry technique on paraffin-embedded tumor tissue were performed. Results: The tumor presented as a painful nodule in the episiotomy scar three months after delivery. Initial treatment included only wide local excision. Six months later local recurrence occurred despite clear surgical margins. Histologically a predominant “classic” cribriform growth pattern was identified. Immunoreactivity in tumor cells supported dual epithelial-myoepithelial diffe­rentiation. Estrogen and progesterone receptors were negative. The DNA histogram revealed a diploid stemline and a low S-phase fraction. Conclusion: ACC of the Bartholin's gland is a rare malignant tumor with great propensity for local recurrence. The optimal the­rapeutic approach has not been established due to the lack of well-defined prognostic parameters.

Adenoid cystic carcinoma
Bartholin’s gland
Flow cytometry
Steroid receptors
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