IMR Press / EJGO / Volume 22 / Issue 1 / pii/2001115

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Malignant mixed mullerian tumor of the ovary: report of four cases

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1 Gynecology Oncology Unit, University of Bari, Bari, Italy
Eur. J. Gynaecol. Oncol. 2001, 22(1), 67–69;
Published: 10 February 2001

Introduction: Malignant mixed mullerian tumor (MMMT) of the ovary is an extremely rare gynaecologic neoplasm that repre­sents I% of the malignances of this organ. Stage I disease is rare because it is asymptomatic in early stage. We describe four cases. Case reports: In the Department of Obstetrics and Gynecology of the University of Bari four cases of MMMT of the ovary were diagnosed. Three patients were in stage IIIC and one of them was a homologous MMMT; the fourth patient was affected by a hete­rologous stage IV MMMT. All women were treated with surgery and chemotherapy. Two patients are alive 14 and 12 months after diagnosis. The other two died after 37 months and one month, respectively. Conclusions: The malignant mixed mullerian tumor (MMMT) of the ovary is a particularly aggressive tumor, especially in advanced stages. The survival rate is very low in spite of surgery, chemotherapy and radiotherapy. The optimal treatment for this neo­plasm is unknown because of its rarity. Our experience, when considering survival, seems to confirm the use of cisplatin and ifosfamide and to give new horizons to taxol.

Ovarian cancer
Ovarian MMMT
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