IMR Press / EJGO / Volume 22 / Issue 1 / pii/2001114

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Microinvasive carcinoma of the cervix. Analysis of prognostic factors

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1 Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Brazil
Eur. J. Gynaecol. Oncol. 2001, 22(1), 64–66;
Published: 10 February 2001
Abstract

Introduction: Superficially invasive neoplasias of the uterine cervix are a matter of controversy in terms of their definition, pro­gnostic factors and selection of treatment to minimize the risk of recurrences. We reviewed our treatment to determine whether any factors affect this risk. Patients and methods: The present study was conducted on 59 patients seen at our service, 22 of them with early stromal invasion (IA1) and 37 with microinvasive carcinoma (IA2) according to FIGO criteria (1995). Ten patients were submitted to conization as definitive treatment, although for three of them treatment was complemented with Wertheim-Meigs surgery due to recur­rence in the remaining cervix. The other 49 patients were submitted to total abdominal hysterectomy. Results: Forty-four patients underwent diagnostic or therapeutic conization, and 14 of them presented involvement of the endocervical margin. Seven patients presented recurrence with involvement of the endocervical margin in five. The age of recurrence ranged from 40 to 70 years, with a mean of 52.3 years, as opposed to a general mean of 42.3 (p < 0.05). Angiolymphatic invasion was positively correlated to recurrence and death (p < 0.01) as well as depth of invasion. Conclusions: We conclude that the presence of a cone with an involved endocervical margin represents a high risk of recurrence and that this condition occurs in older patients who are prone to present more extensive lesions. Thus, age should be regarded as an important risk factor. Angiolymphatic invasion and depth of invasion have a poor prognosis in terms of recurrence and death.

Keywords
Introduction: Superficially invasive neoplasias of the uterine cervix are a matter of controversy in terms of their definition
pro-gnostic factors and selection of treatment to minimize the risk of recurrences. We reviewed our treatment to determine whether any factors affect this risk. Patients and methods: The present study was conducted on 59 patients seen at our service
22 of them with early stromal invasion (IA1) and 37 with microinvasive carcinoma (IA2) according to FIGO criteria (1995). Ten patients were submitted to conization as definitive treatment
although for three of them treatment was complemented with Wertheim-Meigs surgery due to recur-rence in the remaining cervix. The other 49 patients were submitted to total abdominal hysterectomy. Results: Forty-four patients underwent diagnostic or therapeutic conization
and 14 of them presented involvement of the endocervical margin. Seven patients presented recurrence with involvement of the endocervical margin in five. The age of recurrence ranged from 40 to 70 years
with a mean of 52.3 years
as opposed to a general mean of 42.3 (p < 0.05). Angiolymphatic invasion was positively correlated to recurrence and death (p < 0.01) as well as depth of invasion. Conclusions: We conclude that the presence of a cone with an involved endocervical margin represents a high risk of recurrence and that this condition occurs in older patients who are prone to present more extensive lesions. Thus
age should be regarded as an important risk factor. Angiolymphatic invasion and depth of invasion have a poor prognosis in terms of recurrence and death.
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