IMR Press / EJGO / Volume 21 / Issue 2 / pii/2000147

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Is potential to produce inhibins related to prognosis in ovarian granulosa cell tumors?

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1 Department of Obstetrics and Gynecology, Tampere University Hospital, Finland
2 Department of Pathology, University of Tampere, Finland
3 Department of Medical School, University of Tampere, Finland
Eur. J. Gynaecol. Oncol. 2000, 21(2), 187–189;
Published: 10 April 2000
Abstract

Objective: The prognosis of ovarian granulosa cell tumors is difficult to predict by conventional histological methods. Study design: The tumors of 30 patients operated on for a granulosa cell tumor were retrospectively studied for the expression of the inhibin a-subunit. The immunohistochemical staining results were correlated to the FIGO stage of the tumor and the prognosis of the patients. Results: Twenty-six (87%) of the ovarian granulosa cell tumors stained positively for the inhibin a-subunit. All FIGO stage I and II tumors expressed inhibin a-subunit. All FIGO stage l and II tumors expressed inhibin, whereas the majority of stages Ill and IV did not (p = 0.001, χ2-test)/ The survival of the patients with inhibin immunopositive tumors was significantly longer (median 183 months, SE 41, p = 0.000, log rank test) than that of patients without inhibin expression (median 2.5 months, SE 5.25). Conclusions: Patients with ovarian granulosa cell tumors with a potential to produce the inhibin a-subunit may have a more favo­rable prognosis than those with inhibin immunonegative tumors.

Keywords
Inhibins
Immunohistochemistry
Ovarian granulosa cell tumor
Prognostic factors
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