IMR Press / EJGO / Volume 21 / Issue 2 / pii/2000138

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Squamous intraepithelial lesions (SILs) and HPV associated changes in HIV infected women or at risk of HIV

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1 Laboratory of Epidemiology and Biostatistcs, Cytopathology Unit, National Institute of Health, Rome, Italy
2 AIDS Unit, National Institute of Health, Rome, Italy
3 Laboratory of Virology, L. Spallanzani Hospital, IRCCS, Rome, Italy
4 AIDS Unit, L. Spallanzani Hospital, IRCCS, Rome, Italy
5 AIDS Unit, L. Spallanzani Hospital, IRCCS, Rome, Italy
Eur. J. Gynaecol. Oncol. 2000, 21(2), 155–159;
Published: 10 April 2000
Abstract

Objectives: The study concerns the prevalence of squamous intraepithelial lesions (SILs) and the specific cervical cytopatholo­gical features of a group of HIV-positive and a group of HIV-negative women recruited in a multicentric cohort study. The asses­sment of HPV-DNA genotypes was carried out in both groups. Method: 459 women, 266 HIV-positive and 193 HIV-negative women at risk were examined in an Italian multi-institutional study involving 14 gynaecological centres. Results: In our samples, the risk of SILs was 29.4% for HIV-positive women and 10% for HIV-negative women (O.R. = 3.90, C.I. 95%: 2.20-6.98) while HPV-DNA-PCR genotypes had a high prevalence in both groups of HIV-positive and HIV-negative women. Cytopathological features of SILs in HIV-positive women were: a higher number of koilocytes and a more marked atypia of high grade neoplastic cells. Conclusions: A higher prevalence of SILs as well as a specific cervical cytopathology might suggest HIV infection.

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