IMR Press / EJGO / Volume 21 / Issue 2 / pii/2000136

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Adjuvant CMF-chemotherapy and haemostasis. Effect of “classical” and “modified” adjuvant CMF-chemotherapy on blood coagulation fibrinolysis in patients with breast cancer

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1 Center of Gynecology and Obstetrics, Department of Gynecology and Gynecological Oncology, University Hospital Essen, Germany
2 Department of Gynecology and Obstetrics, Friedrich-Ebert-Krankenhaus, Neumiinster, Germany
Eur. J. Gynaecol. Oncol. 2000, 21(2), 147–152;
Published: 10 April 2000
Abstract

Effects of "classical" and "modified" adjuvant CMF-chemotherapy on haemostasis were studied in 22 patients with breast cancer receiving cyclophosphamide (100 mg/m2 p.o.; days 1-14 or 600 mg/m2 i.v.; days 1,8). methotrexate (40 mg/m2 i.v.; days 1,8) and 5-fluorouracil (600 mg/m2 i.v.; days 1,8). Blood collection was done prior to chemotherapy on day 1 and 8. A significant decrease of protein C antigen and activity associated with cumulative effects was observed from day 1 to 8. This effect was similar with “classical” and “modified” CMF-chemotherapy but the reduction of protein C was more pronounced with the oral application of cyclophosphamide. In absence of any significant cumulative decrease of other vitamin K-dependent blood coagulation proteins (factor VII, protein S), the simultaneous decrease of protein C activity and antigen indicates a specific influence of CMF-chemotherapy on vitamin K-dependent protein C-synthesis in the liver.

Keywords
Effects of "classical" and "modified" adjuvant CMF-chemotherapy on haemostasis were studied in 22 patients with breast cancer receiving cyclophosphamide (100 mg/m2 p.o.
days 1-14 or 600 mg/m2 i.v.
days 1
8). methotrexate (40 mg/m2 i.v.
days 1
8) and 5-fluorouracil (600 mg/m2 i.v.
days 1
8). Blood collection was done prior to chemotherapy on day 1 and 8. A significant decrease of protein C antigen and activity associated with cumulative effects was observed from day 1 to 8. This effect was similar with “classical” and “modified” CMF-chemotherapy but the reduction of protein C was more pronounced with the oral application of cyclophosphamide. In absence of any significant cumulative decrease of other vitamin K-dependent blood coagulation proteins (factor VII
protein S)
the simultaneous decrease of protein C activity and antigen indicates a specific influence of CMF-chemotherapy on vitamin K-dependent protein C-synthesis in the liver.
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