IMR Press / EJGO / Volume 21 / Issue 2 / pii/2000129

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Successful conservative treatment of endometrial carcinoma permitting subsequent pregnancy: report of two cases

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1 Department of Obstetrics and Gynecology, School of Medicine, Kitasato University. Kanagawa, Japan
2 Department of Clinical Cytology, Graduate School of Medical Science, Kitasato University. Kanagawa, Japan
Eur. J. Gynaecol. Oncol. 2000, 21(2), 119–122;
Published: 10 April 2000
Abstract

Two women with endometrial carcinoma who wished to preserve their childbearing ability received conservative treatment by medroxyprogesterone acetate (MPA, 600 mg/day for 22 weeks and 29 weeks, respectively). Following regression of endometrial lesions, their infertility was treated by inducing ovulation. Intact pregnancy was diagnosed 13 months and 11 months after com­pletion of the MPA treatment, respectively. One patient had a twin pregnancy and delivered two infants at 35 weeks of gestational age. The other patient delivered a full-term baby. They had no evidence of recurrence 60 months and 31 months after the conser­vative treatment, respectively. We believe this conservative treatment with progestin may be safely performed for young patients with endometrial cancer who wish to preserve their fertility.

Keywords
Endometrial carcinoma
Conservative therapy
Progestin
Fertility
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