IMR Press / EJGO / Volume 21 / Issue 2 / pii/2000128

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Megestrol-induced clinical adrenal insufficiency

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1 Assistant Professor of Obstetrics. Gynecology, and Reproductive Biology, Harvard Medical School Massachusetts General Hospital, Bosaon, USA
2 Assistant Professor of Medicine, Harvard Medical School, Boston, USA
Eur. J. Gynaecol. Oncol. 2000, 21(2), 117–118;
Published: 10 April 2000

Objective: To describe a case of megestrol-induced adrenal insufficiency. Methods: A patient who received megestrol and then developed pituitary-adrenal axis abnormalities is described. The literature is reviewed. Results: The patient developed megestrol-induced Cushingoid features. She developed adrenal insufficiency when megestrol was stopped. Conclusion: Megestrol can induce alterations of the pituitary-adrenal axis in some patients. It is important to consider a diagno­sis of adrenal insufficiency in patients with symptoms of fatigue, hypotension, and asthenia who have been treated with megestrol.

Adrenal insufficiency
Cushingoid features
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