European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Megestrol-induced clinical adrenal insufficiency
Objective: To describe a case of megestrol-induced adrenal insufficiency. Methods: A patient who received megestrol and then developed pituitary-adrenal axis abnormalities is described. The literature is reviewed. Results: The patient developed megestrol-induced Cushingoid features. She developed adrenal insufficiency when megestrol was stopped. Conclusion: Megestrol can induce alterations of the pituitary-adrenal axis in some patients. It is important to consider a diagnosis of adrenal insufficiency in patients with symptoms of fatigue, hypotension, and asthenia who have been treated with megestrol.