IMR Press / EJGO / Volume 21 / Issue 1 / pii/2000112

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Bilateral Krukenberg tumor of the ovary during pregnancy

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1 Institute of Pathology, University Hospital CH UV, Lausanne, Switzerland
2 Department of Gynecology and Obstetrics, University Hospital CH UV, Lausanne, Switzerland
Eur. J. Gynaecol. Oncol. 2000, 21(1), 58–60;
Published: 10 February 2000

This case report concerns a 35-year-old woman suffering from gravidic cholestasis, thrombocytosis and iterative vomiting epi­sodes who underwent an elective cesarean section at week 35 because of recent herpetic vulvitis. Large bilateral ovarian tumors were observed which were interpreted as pregnancy luteomas. Nevertheless a biopsy of the right ovary was performed. Histologic examination revealed massive luteinization of the ovarian stroma. In addition, large tumor cells were found dispersed throughout the ovary as well as in vascular spaces as either isolated or clustered signet-ring cells. In search of the primary tumor, gastroscopy revealed a gastric ulcer in the antrum. The biopsies of the ulcer margins as well as those taken at distance demonstrated signet-ring cells in the lamina propria. Bilateral salpingo-oophorectomy and total gastrectomy were performed. In spite of postoperative che­motherapy, the patient died of disease 5 months after diagnosis.

Krukenberg tumor
Massive luteinization
Luteoma of pregnancy
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