IMR Press / EJGO / Volume 20 / Issue 5-6 / pii/1999201

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Total serum sialic acid concentration as a supporting marker of malignancy in ovarian neoplasia

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1 Department of Physiological Chemistry, Lublin School of Medicine, Lublin, Poland
2 Regional Cancer Centre, Lublin, Poland
Eur. J. Gynaecol. Oncol. 1999, 20(5-6), 389–392;
Published: 10 October 1999
Abstract

The present study was undertaken to establish the diagnostic utility of total sialic acid (SA) determination in the serum of patient with ovarian neoplasia. In a group of 29 patients with histopathologically confirmed ovarian neoplasia, concentrations of total SA was determined. In addition, the two tumor markers: CA125 antigen level and lactic dehydrogenase (LDH) activity were determi­ned. The mean value of serum total SA in patients (I. 76 mmol/L) was significantly higher than in the control group of healthy women (1.52 mmol/L). The elevation of serum total SA was associated with the burden of the tumor: higher total SA levels were observed in the cases of more developed malignancies. A significant correlation has been found between serum total SA content and CA125 level in patients with undifferentiated ovarian cancers. It has been concluded that total serum sialic acid level reflects the development of malignancy and should be considered as a supporting tumor marker in ovarian cancer diagnosis.

Keywords
Sialic acid
Neoplasia of ovary
Tumor markers
CA-125
LDH
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