IMR Press / EJGO / Volume 20 / Issue 4 / pii/1999177

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Benign and malignant mammary tumors induced by DMBA in female Wistar rats

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1 Department of Experimental Research, University Hospital, Coimbra, Portugal
2 Department of Pathology, Faculty of Medicine, University of Coimbra, Portugal
3 Department of Gynaecology, University Hospital, Coimbra, Portugal
Eur. J. Gynaecol. Oncol. 1999, 20(4), 285–288;
Published: 10 August 1999

This study pretends to characterize 7, 12-dimetylbenz[a]anthracene-induced benign and malignant tumors. One hundred and twenty female Wistar rats were randomly allocated to two groups: Control Group and Induction Group; IG animals were given a single dose of DMBA and killed 24 weeks after. Other tumors besides breast tumors were diagnosed, mainly tumors of the salivary glands and ovarian benign epithelial tumors. Incidence of breast disorders was about 60%. Macroscopic mammary tumors varied in dimension from 2 mm to 55 mm. Malignant breast tumors (n = 56) were essentially invasive ductal carcinomas (91.1 %), G 1 (92.2%), presenting histologic characteristics of good prognosis. Predominant benign breast disorders consisted of glandular (68.6%) and atypical (20%) hyperplasias reproducing histologic types of human breast diseases. Different individual susceptibility to DMBA apparently occurs; while some rats never developed neoplasias, others exhibited several tumors.

Benign breast tumors
Breast cancer
Wistar rats
Animal model
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