IMR Press / EJGO / Volume 20 / Issue 4 / pii/1999167

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Radiotherapy with and without chemotherapy after breast conservation surgery for early stage breast cancer: a review of timing

Show Less
1 Division of Radiation Oncology, Louisiana State University School of Medicine, Shreveport, LA, USA
2 Hematology-Oncology, Louisiana State University School of Medicine, Shreveport, LA, USA
3 Surgical Oncology, Louisiana State University School of Medicine, Shreveport, LA, USA
Eur. J. Gynaecol. Oncol. 1999, 20(4), 254–257;
Published: 10 August 1999
Abstract

Purpose: To evaluate the effects in women of the timing of breast irradiation (BI) in relation to the application or non-application of adjuvant chemotherapy after breast conservation surgery (BCS) for early stage cancer. Methods: Between October 1981 and June 1995, 47 women with stage I and II breast cancer underwent BCS. Twenty-six patients did not receive adjuvant chemotherapy (NAC) and 21 women did (AC). In the NAC group, BI commenced within (n=9) or after within 24 weeks. Results: In the NAC group, there was a trend toward more local and systemic failures plus a definite correlation with poorer survival (p=0.05) when BI was initiated more than 7 weeks after BCS. In the AC group, the locoregional and systemic failures occurred only in women with a delay of BI exceeding 24 weeks; survival was not different between the subgroups. Conclusion: An undue delay of BI should be avoided in patients after BCS whether they require adjuvant chemotherapy for early stage breast cancer or not.

Keywords
Breast cancer
Radiotherapy
Chemotherapy
Share
Back to top