IMR Press / EJGO / Volume 20 / Issue 2 / pii/1999129

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Intraepithelial neoplasia and early stage vulvar cancer. Epidemiological, clinical and virological observations

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1 Department of Gynaecology and Oncology, Collegium Medicum, Jagiellonian University, Krakow, Poland
Eur. J. Gynaecol. Oncol. 1999, 20(2), 111–114;
Published: 10 April 1999

Objective: Evaluation of vulvar intraepithelial neoplasia (VIN) and early vulvar cancer risk factor occurrence, frequency, localization and development. Study design: A clinical study carried out on 293 women aged 23-76 years with VIN and vulvar cancer stage I and in a control group of 115 cytologically and colposcopically negative women. Methods: Clinical, colposcopic and morphological evaluation of the localization of YIN and vulvar carcinoma stage I concomitant with intraepithelial neoplasia in other parts of the lower genital tract. Anamnestic inquiry regarding risk factors. In situ hybrid-disation technique for HPV detection. Thomson's method for blood serum vitamin A level assessment. Results and conclusion: An increased frequency of VIN and Ca stage I, especially in young women, has been observed in the past 15 years. In a group of young women under 45 years of age, those lesions were multifocal in 43 cases (63.2%), and unifocal in 25 patients (36.8%). In women over 45 years of age, multifocal lesions occurred in 35 (31.8%), and unifocal in 75 patients (68.2%). HPV infections concomitant with VIN and vulvar cancer stage I occurred in 61.5% of young women and in 17.5% of older females. VIN and stage I vulvar carcinoma coexisted with cervical intraepithelial neoplasia and cervical and/or vaginal cancer in 14 women (7.9%). The risk factor for VIN and early vulvar carcinoma occurrence in young women was different than in older patients. Long-term follow-up of VIN l and VIN 2 showed that in over 1/3 of cases the lesions were persistent or recurred after a transient remission. Progression depended not only on dysplasia stage, but also on histological pattern.

Vulvar intraepithelial neoplasia (VIN)
Early vulvar cancer
Risk factors
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