IMR Press / EJGO / Volume 20 / Issue 1 / pii/1999117

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Malignant potential of gigantic condylomatous lesions of the vulva

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1 Department of Obstetrics and Gynaecology, Medical School, University of Novi Sad, Yugoslavia
2 Department of Gynaecological Oncology, St. Thomas Hospital, London, UK
3 Department of Histopathology, Medical School, University of Novi Sad, Yltgoslavia
Eur. J. Gynaecol. Oncol. 1999, 20(1), 63–66;
Published: 10 February 1999

A diagnostic and therapeutic approach in the identification of malignant lesions and the types of HPV in 11 patients with gigantic condylomatous vulvar protuberances is presented. Different histological types of squamous cell vulvar carcinoma have been found in 8 (72.7%) cases: condylomatous (4), verrucous (3) and basaloid type of the carcinoma (1). HPV type 16, confirmed in 5 cases, was most often present (4 condylomatous and l basaloid carcinoma types). Other types of HPV such as HPV-6 was detected in 3 cases of verrucous, type 11 in 2 cases of verrucous and condylomatous carcinoma and type 18 in l case of condylomatous carcinoma. Radical vulvectomy followed by bilateral inguinofemoral lymphadenectomy was performed in 4 patients with condylomatous carcinoma, hemivulvectomy in basaloid carcinoma whereas wide local excision was performed in the verrucous type of carcinoma. No patient died except 1 with condylomatous carcinoma in whom 6 positive lymph nodes were detected after the primary operation. The patient died 4 years later following 3 excisions of local recurrences.

Giant vulvar condyloma
Squamous cell carcinoma
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