IMR Press / EJGO / Volume 19 / Issue 6 / pii/1998236

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report

Stromal sarcoma arising on endometriosis. A clinicopathological and immunohistochernical study of 4 cases

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1 Department of Pathology, Areteion University Hospital, Athens Medical School, Athens, Greece
2 Department of Pathology, Areteion University Hospital, Athens Medical School, Athens, Greece
3 Department of Pathology, Areteion University Hospital, Athens Medical School, Athens, Greece
Eur. J. Gynaecol. Oncol. 1998, 19(6), 588–590;
Published: 10 December 1998
Abstract

The development of stromal sarcomas on the foci of endometriosis is extremely rare and the differential diagnosis from other tumors of myogenic, vascular, hemopoietic or epithelial origin may present great diagnostic difficulties. We investigated the clinicopathological and immunohistochemical characteristics of 4 cases of endometrial stromal sarcoma that developed on endometriotic foci of the uterus, vagina and omentum. They were classed as high grade (1/4) or low grade (3/4) malignant potential tumors, according to their mitotic activity. Immunohistochemically these tumors gave a positive reaction to vimentin, but were negative to desmin, smooth muscle actin, factor VIII, EMA and LCA. These characteristics permit their identification and a proper therapeutic approach.

Keywords
Stromal sarcoma
Endometriosis
Vimentin
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