IMR Press / EJGO / Volume 19 / Issue 6 / pii/1998227

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Prognostic significance of Bcl-2 and p53 protein expression in stage IIB and IIIB squamous cell carcinoma of the cervix

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1 Department of Molernlar Oncology Cuncer Institute (WIA), Adyar, Madras, India
Eur. J. Gynaecol. Oncol. 1998, 19(6), 556–560;
Published: 10 December 1998
Abstract

Cervical cancer is the most common cancer among women in South India. More than 70% of the cases present in stage TTB and 11IB and of these more than 50% fail conventional treatment. The purpose of the present study was to determine the prognostic significance of Bcl-2 and p53 expression in squamous cell carcinomas of the cervix. Using immunohistochemistry. 40 cases of stage 11B and 11IB squamous cell carcinomas of the cervix treated with radiotherapy were studied for the expression of Bcl-2 and p53 protein and their prognostic value ascertained Bcl-2 was expressed in 65% (n = 26) of the tumours. There was a statistically significant association (p ≤ 0.025) between Bcl-2 expression and poorer DFS and OS in stage 1IB cases. In stage 11IB, these associations were not obvious probably due to additional genetic event、 overshadowing the significance of Bcl-2 expression. Only 4/40 (10%) of the cases were positive for p53 protein expression and there was an inverse correlation between p53 expression and Bcl-2 expression. This study suggests that Bcl-2 can be a useful marker to identify the poor prognostic group in stage IIB cases and needs to be confirmed in a larger series.

Keywords
Cervical cancer
Bcl-2
p53
Prognosis
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