IMR Press / EJGO / Volume 19 / Issue 5 / pii/1998213

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Screening of persistent trophoblastic disease with various serum markers

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1 Doctor Zekai Tahir Burak Women's Hospital Oncology Department, Ankara, Turkey
Eur. J. Gynaecol. Oncol. 1998, 19(5), 495–497;
Published: 10 October 1998
Abstract

Eighty percent of the patients with molar pregnancy go into spontaneous remission and do not require any therapy. Serial hCG determinations can identify the 20% who will develop malignant sequelae. It does not seem appropriate to treat all patients. This study was designed to assess several serum markers, including free β-hCG, total β-hCG, and CA-125 in order to identify persistent trophoblastic disease. The study was performed at Doctor Zekai Tahir Burak Women's Hospital, Department of Oncology. Forty-seven patients with complete hydatidiform mole were included in the study. In the spontaneous remission group (Group 1), total βhCG, CA-125 and freeβhCG values were 27988.7 ± 18491.6 mlU/ml, 51.7 ± 74.7 U/ml and 42.35 ± 28.4 mlU/ml, respectively. Patients in whom persistent trophoblastic disease had developed (Group II) the mean serum CA-125 and mean total βhCG values were lower than in group I, whereas the mean free βhCG value was higher but not significant. The mean value of free βhCG per total βhCG was found to be significantly higher in group 2. The free βhCG per total βhCG ratio seems to be a sensitive predictor of persistency of trophoblastic disease. Further prospective studies with a larger series of patients may warrant the exact predictive value of free βhCG per total hCG ratios.

Keywords
Persistent trophoblastic disease
Free beta human chorionic gonodotropine
Total beta human chorionic gonodotropine
Cancer antigen-125
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