IMR Press / EJGO / Volume 19 / Issue 3 / pii/1998169

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

High-risk gestational trophoblastic disease: analysis of clinical prognoses

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1 Departments of Obstetrics and Gynecology, Veterans General Hospital - Taipei, National Yang-Ming University School of Medicine, Taipei, Taiwan
Eur. J. Gynaecol. Oncol. 1998, 19(3), 302–304;
Published: 10 June 1998

Purpose of investigation: An attempt to better define factors leading to patient survival in the high-risk group of malignant gesta­tional trophoblastic disease (GTD). Methods: From January 1, 1997 to December 31, 1995 25 cases of malignant high-risk GTD were retrospectively collected to evaluate prognostic factors by univariate and multivariate analysis. Results: We identified the presence of liver metastases and/or brain metastases and the presence of intestinal metastases as signi­ficant by using univariate analysis. However, only the presence of liver metastases of brain metastases was significant by multiva­riate analysis (p = 0.009). Conclusions: Although a high-risk group of GTD can be identified according to the modified World Health Organization (WHO) prognostic scoring system, liver metastases were not emphasized (only two points) in this scoring system. We suggested that these risk factors, including brain metastases and liver metastases, should be weighted more than other risk factors.

Malignant gestational trophoblastic disease
Liver metastases or brain metastases
Prognostic factors
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