IMR Press / EJGO / Volume 19 / Issue 3 / pii/1998162

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Catheter complications associated with intraperitoneal chemotherapy

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1 Institute of Oncology, Department of Medical Oncology, University of Istanbul, Turkey
2 Faculty of Medicine, Department of Gynecological Oncology, University of Istanbul, Turkey
3 Institute of Oncology, Department of Surgical Oncology, University of Istanbul, Turkey
Eur. J. Gynaecol. Oncol. 1998, 19(3), 275–279;
Published: 10 June 1998

Catheter complications associated with intraperitoneal chemotherapy were evaluated in 171 patients (pts) with primary intra­abdominal malignancies. In 96 pts and 488 courses, single-use catheters (SUC) (3/G 14 Braun) were used between years 1990-1993. In 75 pts and 283 courses a semi-permanent subcutaneous implantable port and catheter system (SIPC) (T 2035/460 mm-F 14-76 Braun) was used between years 1993-1996. Cisplatin (60-75 mg/sqm), 5-fluorouracil (600 mg/sqm), calcium folinate (150 mg), eto­poside (180 mg/sqm), mitoxantrone (12-15 mg/sqm) were given in various combinations and periods to patients with ovarian car­cinoma (106 pts), gastrointestinal carcinoma (43 pts), hepatocellular carcinoma (17 pts) and mesothelioma (5 pts). The incidence of patients with complications was significantly higher in SUC (45%) than SIPC (23%) (p = 0.001). Colon puncture (8.8%, p < 0.0001) and subcutaneous leakage (3.7%, p < 0.01) rate of the courses were significantly higher in SUC. Pain related to catheter complica­tions (6%, p < 0,0002), local infection (1.4%, p = 0.02) and obstruction (1.4%, p = 0.02) were significantly higher in SIPC. The most important local complications were intra-abdominal fibrosis and adhesions that were surgically documented in 90% of the ovarian cancer patients, and were more severe in patients with the SIPC system. The complication rate and the complication type of these two catheters were found to be significantly different in this retrospective analysis; in order to determine the real complication rate, safety, efficacy and overall acceptability of the catheters, a randomised trial is needed.

Intraperitoneal chemotherapy
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